Experiment Shows Regrowth of Spinal Cord Fibers
April 28, 2000
Source: Reuters
BOSTON (Reuters) - A nerve growth factor, Inosine, stimulated regrowth of severed
spinal cord motor nerve fibers in an experiment on laboratory rats, Boston Life Sciences
Inc. said on Friday.
The company said the regrowth was being accomplished experimentally for the first time
and could bring Inosine, which occurs naturally in the body, closer to human trials.
In the experiment, Inosine was administered to rats with severed spinal cords. In four
of the five treated rats, new fibers were seen coursing through the injury to reestablish
connections, the company said.
Dr. Marc Lanser, the chief scientific officer of the company, said in a statement that
he hoped to submit the results for publication shortly. "This represents a giant step
forward in our spinal cord program since these results indicated that motor function can
potentially be reestablished under the control of the same area of the brain that gave
rise to the injured spinal cord fibers," he said.
In an experiment published in the Proceedings of the National Academy of Sciences late
last year, an experiment showed cross-over sprouting of motor axons, a part of a nerve
cell, in injured spinal cords, the company said.
Boston Life planned to duplicate the results of the experiment in primates before
starting human clinical trials.
Boston Life Sciences has been developing Inosine and another nerve growth factor, AF-1,
for regenerative treatment of spinal cord injuries and stroke.
In February, the company's collaborating scientists isolated the molecule that
responded to AF-1 and Inosine. The target was an enzyme within the central nervous
system's neurons that controlled nerve growth in the brain, or in the spinal cord.
Inosine is a molecule formed by the breakdown of adenosine, a building block of genetic
material and an important signaling molecule.
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